ea0015oc37 | Thyroid | SFEBES2008
Reed Anita AC
, Loh Nellie
, Lippiat Jonathan
, Partridge Chris
, Galvanovskis Juris
, Williams Sian
, Jouret Francois
, Wu Fiona
, Courtoy Pierre
, Nesbit M Andrew
, Devuyst Olivier
, Rorsman Patrik
, Ashcroft Frances
, Thakker Rajesh V
Endocrine cells utilise endocytosis to scavenge polypeptide hormones, and to generate signals from inactive precursors, such as release of thyroid hormones from thyroglobulin in thyrocytes, and activation of vitamin D after reabsorption of ultrafiltrated pro-vitamin D binding protein complex by renal proximal tubular cells (PTC). We have investigated the role of CLC-5, a chloride/proton antiporter expressed in apical endosomes and the apical plasma membrane of thyrocytes and P...